Get your popcorn ready! Week 1 of the NFL season is upon us.
The 2026 season kicks off in style with a a Super Bowl rematch between the defending champion Seattle Seahawks and the New England Patriots at Lumen Field in Seattle. The Seahawks, who disposed of the Patriots 29-13 to cap last season’s championship run, are 3.5-point favorites for Wednesday night’s opener.
The action continues one night later when the Los Angeles Rams host the San Francisco 49ers on Thursday night in a clash of NFC West rivals. Both teams went 12-5 last season, and both teams’ seasons came to an end in the playoffs at the hands of the Seahawks. The Rams are a 3.5-point favorite over the 49ers.
Sunday gives us a 13-game slate, with the Buffalo Bills–Houston Texans matchup highlighting the early afternoon games. The Texans come in as slight favorites. The Sunday night game features a classic NFC East rivalry, as the Dallas Cowboys visit the New York Giants as 3-point road favorites.
A whopping 12 Week 1 games have spreads of 3.5 points or less. The Los Angeles Chargers are the biggest favorite of the week, laying 10 points to the Arizona Cardinals. The Tampa Bay Buccaneers–Cincinnati Bengals matchup has the highest total of the week at 50.5.
The week wraps up with Patrick Mahomes making his comeback from a torn ACL when the Kansas City Chiefs (-3, 42.5) host the Denver Broncos on “Monday Night Football” (8:15 ET on ABC/ESPN).
Here’s a look at the odds for every Week 1 game.
Note: Odds by DraftKings
and subject to change.
Jump to:
NE-SEA | SF-LAR | TB-CIN | NO-DET
NYJ-TEN | BAL-IND | ATL-PIT | CHI-CAR
CLE-JAX | BUF-HOU | MIA-LV | GB-MIN
WSH-PHI | ARI-LAC | DAL-NYG | DEN-KC
Wednesday
New England Patriots at Seattle Seahawks (-3.5)
8:20 p.m. ET on NBC, Lumen Field, Seattle
Moneyline: Seahawks -180, Patriots +150
Total: 45.5 points
FPI favorite: Seahawks by 3.4, 61.1% to win outright
Thursday
San Francisco 49ers vs. Los Angeles Rams (-3.5)
8:35 p.m. ET on Netflix, Melbourne Cricket Ground, Melbourne, Australia
Moneyline: Rams -185, 49ers +154
Total: 48.5 points
FPI favorite: Rams by 2.9, 60.5% to win outright
Sunday
Tampa Bay Buccaneers at Cincinnati Bengals (-3.5)
1 p.m. ET on FOX, Paycor Stadium, Cincinnati
Moneyline: Bengals -198, Buccaneers +164
Total: 50.5 points
FPI favorite: Bengals by 3.2, 61.6% to win outright
New Orleans Saints at Detroit Lions (-7)
1 p.m. ET on FOX, Ford Field, Detroit
Moneyline: Lions -290, Saints +235
Total: 49.5 points
FPI favorite: Lions by 6.8, 71.9% to win outright
Check out each team’s futures odds here. For the latest, visit DraftKings.
New York Jets at Tennessee Titans (-1.5)
1 p.m. ET on CBS, Nissan Stadium, Nashville, Tenn.
Moneyline: Titans -125, Jets +105
Total: 39.5 points
FPI favorite: Titans by 2.1, 57.6% to win outright
Baltimore Ravens (-3) at Indianapolis Colts
1 p.m. ET on CBS, Lucas Oil Stadium, Indianapolis
Moneyline: Ravens -162, Colts +136
Total: 47.5 points
FPI favorite: Ravens by 2.4, 59.0% to win outright
Atlanta Falcons at Pittsburgh Steelers (-3.5)
1 p.m. ET on FOX, Acrisure Stadium, Pittsburgh
Moneyline: Steelers -185, Falcons +154
Total: 42.5 points
FPI favorite: Steelers by 2.6, 58.9% to win outright
Chicago Bears (-3) at Carolina Panthers
1 p.m. ET on FOX, Bank of America Stadium, Charlotte, N.C.
Moneyline: Bears -148, Panthers +124
Total: 46.5 points
FPI favorite: Bears by 2.6, 59.6% to win outright
Cleveland Browns at Jacksonville Jaguars (-7.5)
1 p.m. ET on CBS, EverBank Stadium, Jacksonville, Fla.
Moneyline: Jaguars -380, Browns +300
Total: 40.5 points
FPI favorite: Jaguars by 7.8, 77.3% to win outright
Buffalo Bills at Houston Texans (-1.5)
1 p.m. ET on CBS, NRG Stadium, Houston
Moneyline: Bills -118, Texans -102
Total: 44.5 points
FPI favorite: Bills by 1.1, 53.5% to win outright
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Miami Dolphins at Las Vegas Raiders (-3.5)
4:25 p.m. ET on FOX, Allegiant Stadium, Las Vegas
Moneyline: Raiders -185, Dolphins +154
Total: 40.5 points
FPI favorite: Raiders by 2.8, 59.8% to win outright
Green Bay Packers at Minnesota Vikings (-1.5)
4:25 p.m. ET on CBS, U.S. Bank Stadium, Minneapolis
Moneyline: Vikings -122, Packers +102
Total: 46.5 points
FPI favorite: Packers by 1.8, 56.6% to win outright
Washington Commanders at Philadelphia Eagles (-4.5)
4:25 p.m. ET on FOX, Lincoln Financial Field, Philadelphia
Moneyline: Eagles -205, Commanders +170
Total: 44.5 points
FPI favorite: Eagles by 4.9, 66.5% to win outright
Arizona Cardinals at Los Angeles Chargers (-10)
4:25 p.m. ET on CBS, SoFi Stadium, Inglewood, Calif.
Moneyline: Chargers -625, Cardinals +455
Total: 47.5 points
FPI favorite: Chargers by 9.6, 80.8% to win outright
Dallas Cowboys (-3) at New York Giants
8:20 p.m. ET on NBC, MetLife Stadium, East Rutherford, N.J.
Moneyline: Cowboys -155, Giants +130
Total: 48.5 points
FPI favorite: Cowboys by 2.0, 57.2% to win outright
Monday
Denver Broncos at Kansas City Chiefs (-3)
8:15 p.m. ET on ESPN/ABC, GEHA Field at Arrowhead Stadium, Kansas City, Mo.
Moneyline: Chiefs -155, Broncos +130
Total: 43.5 points
FPI favorite: Chiefs by 2.5, 58.5% to win outright
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